Genetics of the right ventricle

Presented at Genetics-inspired Therapeutics for PH by Lars Harbaum, Universitätsklinikum Hamburg-Eppendorf

Summary

This presentation delves into the critical role of human genetics in understanding right ventricular biology within pulmonary hypertension. It highlights intrinsic RV factors like inflammation and metabolism, alongside the significant impact of BMP signaling pathways and BMPR2 mutations. Large-scale imaging studies reveal distinct genetic determinants for RV function, with implications for inherited cardiomyopathies and disease incidence.

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