Renal Recovery Patterns and Long-Term Kidney Function Decline in Pulmonary Hypertension

4 June 2026

Lukas Hintz, Anastasios Stampouloglou, Janani Rangaswami, Kevin Brian Lo, Werner Seeger, Hossein-Ardeschir Ghofrani, Henning Gall, Khodr Tello, Faeq Husain-Syed

https://doi.org/10.1002/pul2.70336

Abstract

Pulmonary hypertension (PH) is frequently accompanied by a decline in kidney function. In this retrospective cohort, worsening PH was associated with long-term eGFR decline only when accompanied by transition from acute kidney injury (AKI) to acute kidney disease (AKD), defined as persistent kidney dysfunction beyond 7 days after AKI onset, whereas early AKI reversal was not. These findings suggest that renal recovery patterns, rather than transient changes in kidney function, may determine longitudinal kidney outcomes in PH and warrant further prospective investigation.

Read the full research letter

Other materials on this topic

20 February 2026

February 2026 PVRI Community Call

In this PH Community Call, we discussed:

Subcutaneous Treprostinil in PH Associated With Left Heart Disease or Chronic Lung Disease
Ferroportin Inhibition Attenuates Pulmonary Hypertension in Hypoxic Sickle Cell Disease Mice
Artificial Intelligence-Based Echocardiography in Pulmonary Arterial Hypertension

Community Calls

10 February 2026

Platelet activation & macrophage recruitment drive vascular dysfunction in a murine model of sickle cell PH

Presented at PVRI 2026 Congress by Daniel Colon Hidalgo, University of Colorado

Congresses & Symposia

28 January 2026

Sotatercept in Pulmonary Langerhans Cell Histiocytosis-Associated Pulmonary Hypertension: A Case Series and Systematic Review

Pulmonary Langerhans cell histiocytosis (PLCH) frequently complicated by pulmonary hypertension (PH), which markedly worsens prognosis. We retrospectively reviewed three institutional PLCH-PH cases treated with off-label Sotatercept added to background triple therapy and performed a systematic review of published PLCH-PH reports (PubMed/Embase through May 2025).

Pulmonary Circulation

22 December 2025

Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis

Schistosomiasis and sickle cell disease (SCD) both cause pulmonary hypertension (PH). We identified a subject with sickle cell trait and hepatosplenic schistosomiasis, who on right heart catheterization had PH, but due to high cardiac output. In a pre-clinical model, we found SCD mice were protected from developing schistosomiasis-induced PH.