Combination Use of Sildenafil and Simvastatin Increases BMPR-II Signal Transduction in Rats with Monocrotaline-Mediated Pulmonary Hypertension

PVRI Member Authors: Jason Yuan

Dysfunctional bone morphogenetic protein (BMP) signaling has been found in patients with pulmonary arterial hypertension (PAH); however, the exact role of BMP signaling in the treatment of PAH remains unknown. The BMP receptor type II (BMPR-II) is a member of the TGF-β family of signaling molecules. Functional receptors are heterodimers composed of a BMPR-II subunit and a serine-threonine kinase type I subunit, of which there are three members: BMPR-Ia, BMPR-Ib and Alk2.[1,2] Both BMPR-II and BMPR-Ia/Ib are highly expressed in the pulmonary vascular smooth muscle and endothelium. The discovery of heterozygous mutations of the BMPR-II gene (BMPR2) in patients with hereditary (or familial) PAH and patients with idiopathic PAH [3,4] represented a significant advance in the understanding of the genetic contributions to PAH.

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Topics

Endothelin and Endothelium & Epithelium and Epithelial Transport
Epigenetics and Epigenomics

Authors

Tuguang Kuang, Jun Wang, Amy Zeifman, Baosen Pang, Xiuxia Huang, Elyssa D. Burg, Jason X.-J. Yuan, Chen Wang

Published in:

Pulmonary Circulation Vol 1: No 1 cover image

March 2011

Pulmonary Circulation Vol 1: No 1

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