The 55th annual Thomas L. Petty Aspen Lung Conference, “Mechanics and Mechanisms of Pulmonary Hypertension,” was held in June of 2012, as it is every year in beautiful Aspen, Colorado. In developing this year's conference, we sought to emphasize the integration of basic, translational, and clinical science in what is arguably the most rapidly progressing field in pulmonary medicine. The more recent appreciation of the importance of the right ventricle (RV) and right ventricular-pulmonary arterial (RV-PA) interaction in patient outcomes also Required due diligence in the design of the program. We sought to highlight the dramatic strides being made in a variety of areas of pulmonary hypertension (PH) and capture the excitement surrounding these discoveries. We hoped to stimulate active discussion and debate among experts in a variety of areas of pulmonary vascular disease, and help to drive our understanding forward. Lastly, we wished to facilitate future collaborations that will advance the field. By all accounts, we believe this year's conference was a success.