Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series)

Abstract

Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action. In the cardiovascular system, epigenetic regulation affects development, differentiation, and disease propensity or expression. Defining the determinants of epigenetic regulation offers opportunities for novel strategies for disease prevention and treatment.

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Topics

Atherosclerosis
Epigenetics and Epigenomics
Pulmonary Hypertension

Authors

Joseph Loscalzo, Diane E. Handy

Published in:

Pulmonary Circulation Vol 4: No 2 cover image

May 2014

Pulmonary Circulation Vol 4: No 2

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