The emerging role of metabolomics in the development of biomarkers for pulmonary hypertension and other cardiovascular diseases (2013 Grover Conference series)

PVRI Member Authors: Gregory Lewis

Abstract

The functional and prognostic significance of pulmonary hypertension (PH) is well established, yet our understanding of circulating peptides and metabolites that might mark or contribute to various forms of PH remains limited. Metabolites are the end result of all the regulatory complexity present in a cell, tissue, or organism and therefore serve as the most proximal reporters of the body's response to a disease process or drug therapy. This review presents the rationale, methodology, and preliminary findings from studies that apply comprehensive metabolite profiling to gain knowledge of new circulating markers of PH.

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Topics

Biomarkers
Cell Biochemistry and Metabolism, Differentiation and Proliferation, Structure and Function, interactions
Exercise
Functional Ability/ Impairment/ Quality of Life/ Physical Activity/ Exercise
Proteomics
Pulmonary Hypertension

Authors

Gregory D. Lewis

Published in:

Pulmonary Circulation Vol 4: No 3 cover image

August 2014

Pulmonary Circulation Vol 4: No 3

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