Mechanisms regulating endothelial permeability

Abstract

The endothelial monolayer partitioning underlying tissue from blood components in the vessel wall maintains tissue fluid balance and host defense through dynamically opening intercellular junctions. Edemagenic agonists disrupt endothelial barrier function by signaling the opening of the intercellular junctions leading to the formation of protein-rich edema in the interstitial tissue, a hallmark of tissue inflammation that, if left untreated, causes fatal diseases, such as acute respiratory distress syndrome. In this review, we discuss how intercellular junctions are maintained under normal conditions and after stimulation of endothelium with edemagenic agonists. We have focused on reviewing the new concepts dealing with the alteration of adherens junctions after inflammatory stimulus. 

Read the full article online

Topics

Cell Biochemistry and Metabolism, Differentiation and Proliferation, Structure and Function, interactions
Endothelin and Endothelium & Epithelium and Epithelial Transport
Pulmonary Endothelium

Authors

Sukriti Sukriti, Mohammad Tauseef, Pascal Yazbeck, and Dolly Mehta

Published in:

Pulmonary Circulation Vol 4: No 4 cover image

December 2014

Pulmonary Circulation Vol 4: No 4

View this journal

Our research platform is the world.

Through worldwide collaboration, we can begin to answer the question of a global disease.

Join the PVRI
standard-example-image.jpg