Pregnancy as a possible trigger for heritable pulmonary arterial hypertension

PVRI Member Authors: David Langleben, Andrew M Hirsch


It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coincidence in a disease that predominates in young women. We describe a carrier of a BMPR2 gene mutation who had an uneventful first pregnancy but had aggressive PAH during her second pregnancy and now has ongoing heritable PAH. The possible role of pregnancy as a trigger in this vulnerable patient is discussed. Databases of patients with heritable PAH should be explored to see whether pregnancy is related to overt manifestation of the disease.

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Pregnancy and Pediatrics: Pulmonary Vascular Disease
Pulmonary Arterial Hypertension


Maude Limoges, David Langleben, Benjamin D. Fox, Roberta Shear, Paul Wieczorek, Lawrence G. Rudski, Andrew M. Hirsch, Robert D. Schlesinger, Lyda Lesenko

Published in:

Pulmonary Circulation Vol 6: No 3 cover image

September 2016

Pulmonary Circulation Vol 6: No 3

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