Pregnancy as a possible trigger for heritable pulmonary arterial hypertension

PVRI Member Authors: David Langleben, Andrew M Hirsch

Abstract

It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coincidence in a disease that predominates in young women. We describe a carrier of a BMPR2 gene mutation who had an uneventful first pregnancy but had aggressive PAH during her second pregnancy and now has ongoing heritable PAH. The possible role of pregnancy as a trigger in this vulnerable patient is discussed. Databases of patients with heritable PAH should be explored to see whether pregnancy is related to overt manifestation of the disease.

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Topics

Pregnancy
Pregnancy and Pediatrics: Pulmonary Vascular Disease
Pulmonary Arterial Hypertension

Authors

Maude Limoges, David Langleben, Benjamin D. Fox, Roberta Shear, Paul Wieczorek, Lawrence G. Rudski, Andrew M. Hirsch, Robert D. Schlesinger, Lyda Lesenko

Published in:

Pulmonary Circulation Vol 6: No 3 cover image

September 2016

Pulmonary Circulation Vol 6: No 3

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