Right ventricular ST-elevation myocardial infarction as a cause of death in idiopathic pulmonary arterial hypertension

PVRI Member Authors: David Langleben

Abstract

A 32-year-old woman with advanced idiopathic pulmonary arterial hypertension (PAH), treated with oral tadalafil and intravenous epoprostenol, presented with typical angina pectoris of one day’s duration. Her electrocardiogram, previously typical of pulmonary hypertension, revealed an acute ST-elevation myocardial infarction in the anterior precordial leads. She had a prior coronary angiogram, in preparation for lung transplantation, that revealed normal coronary arteries. Urgent coronary angiography showed acute occlusion of several acute marginal coronary branches that feed the right ventricle (RV). Coronary angioplasty and stenting was unable to adequately restore coronary perfusion. Despite support, she developed progressive cardiogenic shock and died three days later. This is an unusual complication of PAH.

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Topics

Coronary Disease
Myocardium, Myocytes and Myocardial Contraction/ Infarction/ Ischemia/ Myocarditis
Pulmonary Arterial Hypertension
Right Ventricle: Structure, Function and Dysfunction

Authors

Yang Zhan, Barry Burstein, Ali O. Abualsaud, Mohamed Nosair, Andrew M. Hirsch, Lyda Lesenko, David Langleben

Published in:

Pulmonary Circulation Vol 7: No 2 cover image

May 2017

Pulmonary Circulation Vol 7: No 2

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