Identity crisis in pulmonary arterial hypertension

PVRI Member Authors: Sebastien Bonnet, Steeve Provencher, Frederic Perros

Abstract

Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity crisis: the ectopic expression of normally silent tissue-specific genes.

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Topics

Pulmonary Arterial Hypertension
Pulmonary Hypertension

Authors

G. Ruffenach, S. Rousseaux, S. Khochbin

Published in:

Pulmonary Circulation Vol 8: No 1 cover image

March 2018

Pulmonary Circulation Vol 8: No 1

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