Lipopolysaccharide acutely suppresses right-ventricular strain in rats with pulmonary artery hypertension

Abstract

Worsening right ventricular (RV) dysfunction in the presence of pulmonary artery hypertension (PAH) increases morbidity and mortality in this patient population. Transthoracic echocardiography (TTE) is a non-invasive modality to evaluate RV function over time. Using a monocrotaline-induced PAH rat model, we evaluated the effect of acute inflammation on RV function. In this study, both PAH and control rats were injected with Escherichia coli lipopolysaccharide (LPS) to induce an acute inflammatory state. We evaluated survival curves, TTE parameters, and inflammatory markers to better understand the mechanism and impact of acute inflammation on RV function in the presence of PAH. The survival curve of the PAH rats dropped sharply within 9 h after LPS treatment. . . . .

Read the full article online

Topics

Pulmonary Hypertension
Right Ventricle: Structure, Function and Dysfunction

Authors

Junjie Zhang, Yanan Cao, Xiaowei Gao, Maoen Zhu, Zhong Zhang, Yue Yang, Qulian Guo, Yonggang Peng, E. Wang

Published in:

Pulmonary Circulation Vol 8: No 1 cover image

March 2018

Pulmonary Circulation Vol 8: No 1

View this journal

Our research platform is the world.

Through worldwide collaboration, we can begin to answer the question of a global disease.

Join the PVRI
standard-example-image.jpg