Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients

PVRI Member Authors: Robbert Rottier, Dick Tibboel


We show that hypoxia inducible factor 2α (HIF2α) is highly expressed in patients with pulmonary hypertension (PH). HIF2α is expressed in every patient with congenital diaphragmatic hernia, while only half of the controls express HIF2α. Our data suggest that HIF2α is a link between hypoxia and the development of PH.

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Endothelin and Endothelium & Epithelium and Epithelial Transport
Hypoxia/ Intermittent Hypoxia/ Hypoxia-Ischemia and Ischemia-Reperfusion Injury
Pulmonary Arterial Hypertension


Yadi Huang, Anne Boerema-de Munck, Marjon Buscop-van Kempen, Ilona Sluiter, Ronald de Krijger

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Pulmonary Circulation Vol 8: No 3 cover image

September 2018

Pulmonary Circulation Vol 8: No 3

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