Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice

Abstract

We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilation-perfusion matching at the acinar level.

Read the full article online

Topics

Hypoxia/ Intermittent Hypoxia/ Hypoxia-Ischemia and Ischemia-Reperfusion Injury
Vasoreactivity: Vasoconstriction and Vasodilatation

Authors

Ghulam Murtaza, Renate Paddenberg, Uwe Pfeil, Anna Goldenberg, Petra Mermer, Wolfgang Kummer

Published in:

Pulmonary Circulation Vol 8: No 4 cover image

December 2018

Pulmonary Circulation Vol 8: No 4

View this journal

Our research platform is the world.

Through worldwide collaboration, we can begin to answer the question of a global disease.

Join the PVRI
standard-example-image.jpg