Drug repositioning in pulmonary arterial hypertension: challenges and opportunities

PVRI Member Authors: Dan Grinnan, Bruce Bloom, Edda Frauke Spiekerkoetter

Abstract

Despite many advances in medical therapy for pulmonary arterial hypertension (PAH) over the past 20 years, long-term survival is still poor. Novel therapies which target the underlying pathology of PAH and which could be added to current vasodilatory therapies to halt disease progression and potentially reverse pulmonary vascular remodeling are highly sought after. Given the high attrition rates, substantial costs, and slow pace of new drug development, repositioning of “old” drugs is increasingly becoming an attractive path to identify novel treatment options, especially for a rare disease such as PAH.

We here summarize the limitations of current PAH therapy, the general concept of repurposing and repositioning, success stories of approved repositioned drugs in PAH as well as novel repositioned drugs that show promise in preclinical models of pulmonary hypertension (PH) and are currently tested in clinical trials. We furthermore discuss various data-driven as well as experimental approaches currently used to identify repurposed drug candidates and review challenges for the “repositioning community” with regards to funding and patent and regulatory considerations, and to illustrate opportunities for collaborative solutions for drug repositioning relevant to PAH.

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Topics

Pulmonary Arterial Hypertension
Pulmonary Hypertension
Pulmonary Vascular Remodeling
Survival

Authors

Daniel Grinnan, Cory Trankle, Adam Andruska, Bruce Bloom, Edda Spiekerkoetter

Published in:

Pulmonary Circulation Vol 9: No 1 cover image

March 2019

Pulmonary Circulation Vol 9: No 1

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