Pulmonary embolism (PE) remains a major cause of morbidity and mortality in hospitalized patients and is a top cause of cardiovascular death behind myocardial infarction and stroke, two disease states which have seen the formalization of team-based care that can be rapidly activated and deployed for expeditious and expert treatment. Only recently in this decade, and in conjunction with the advances of new therapeutic options for PE including catheter-directed thrombolysis and thromboaspiration, have we seen the emergence of the PE Response Team (PERT) in an attempt to improve care for this deadly disease. First described by Massachusetts General Hospital and in operation since 2013, the PERT is modeled off of the deployment of Rapid Response Teams meant to bring specialized resources to hospitalized patients in an effort to rescue and prevent further deterioration. The team can be rapidly activated and expert care from multiple stakeholder specialties can be planned and coordinated with the patient and primary physician. Modeled after this team approach, PERTs have rapidly spread in hospitals across America and, in 2015, the PERT Consortium® was created to help focus ongoing mission goals, including the creation of registry data on patients treated under this care model. At the time of publication, the PERT Consortium® comprises over 60 founding and institutional member hospitals.