Pathophysiology, incidence, management, and consequences of cardiac arrhythmia in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

PVRI Member Authors: John Ryan, Stephen Archer

Abstract

Arrhythmias are increasingly recognized as serious, end-stage complications of pre-capillary pulmonary hypertension, including pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Although arrhythmias contribute to symptoms, morbidity, in-hospital mortality, and possibly sudden death in PAH/CTEPH, there remains a paucity of epidemiologic, pathophysiologic, and outcome data to guide management of these patients. This review summarizes the most current evidence on the topic: from the molecular mechanisms driving arrhythmia in the hypertrophied or failing right heart, to the clinical aspects of epidemiology, diagnosis, and management.

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Topics

Arrhythmia
Pathology and Pathophysiology
Survival

Authors

Meghan M. Cirulis, John J. Ryan, Stephen L. Archer

Published in:

Pulmonary Circulation Vol 9: No 1 cover image

March 2019

Pulmonary Circulation Vol 9: No 1

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