It is my sincere pleasure to invite you to please register for the Vera Moulton Wall Center’s 4th International Symposium “From Precision Biology to Precision Medicine in Pulmonary Hypertension: Revolutionizing Healthcare through Revolutionary Science”, scheduled for May 18, 2018 to be held at the Sheraton Hotel. A live stream of this event is available from the registration page of the Stanford site.
Despite numerous recent advances in pulmonary arterial hypertension (PAH), additional research is warranted to better understand disease pathogenesis, identify and deconstruct novel sources of biological and clinical heterogeneity across patients, and pave a road to new treatment paradigms.
The exciting field of precision biology arms researchers with powerful tools to study PAH pathobiology, such as single cell transcriptomics, spatial proteomics, lineage tracing and the use of induced pluripotent stem cells to model disease in a dish. These cutting-edge methods have the potential to transform the way we understand disease pathogenesis, identify specific treatment targets, and develop precise and highly effective PAH therapies.
Precision medicine is a therapeutic strategy that takes into account individual variability in genes, environment, and lifestyle to identify clinical phenotypes that would specifically benefit from targeted therapies. The importance of precision medicine to the future of US health care has been stressed by president Obama in his Precision Medicine Initiative, which aims to provide clinicians with a way to integrate seemingly disparate data (e.g. genetics, proteomics, epigenetics, metabolomics, medical record data, etc.) into a framework that improves individual clinical outcomes and health care quality. Given the rapid advancement of high-throughput ‘Omics’ platforms, availability of sophisticated machine learning algorithms, and emergence of collaborative PAH biorepositories and phenotyping efforts, the time is ripe to discuss how state-of-the-art technologies can facilitate the translation of scientific discoveries into clinical tools for improved diagnosis and treatment of PAH patients.
Hope to see you there!
Vinicio A. de Jesus Perez