01 January 2015 by Nick Morrell

Activation of BMP receptors leads to phosphorylation of Smads and activation of extracellular signal regulated kinases (ERKs)

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Morrell {NW}.{TGF--related} molecules and pulmonary vascular remodeling in familial and nonfamilial pulmonary arterial hypertension. [Internet]. 2009 ;1:42. Available from:http://www.pvrireview.org/text.asp?2009/1/1/42/44889

Activation of BMP receptors leads to phosphorylation of Smads and activation of extracellular signal regulated kinases (ERKs). ERK activation limits the c-terminus phosphorylation of Smad1/5. Stimulation of ERK by receptor tyrosine kinases (RTKs) can further limit Smad c-terminus phosphorylation. These effects are integrated at the level of Id gene expression which then have critical roles in cell differentiation and proliferation.

 

Additional keywords: ERK,tyrosine kinase inhibitor,smad,FPAH

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