01 January 2015 by Kurt R Stenmark, Michael Yeager

Animal models of pulmonary hypertension are consistently characterized by adventitial/peri-vascular accumulation of leukocytes, and in particular mononuclear cells

AI00029.jpg
Stenmark {KR},Yeager M,Riddle S,El Kasmi {KC},Frid {MG},Li M,{McKinsey} T.Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change. [Internet]. 2012 ;2:3. Available from:http://www.pulmonarycirculation.org/text.asp?2012/2/1/3/94817

Animal models of pulmonary hypertension are consistently characterized by adventitial/peri-vascular accumulation of leukocytes, and in particular mononuclear cells. (A) Illustrates the accumulation of mononuclear cells/macrophages in the adventitial/ perivascular regions of chronically hypoxic rats, calves, and mice. (B) Perivascular accumulation of mononuclear cells (CD14+ cells) is observed in the human patient with iPAH. (C) Mouse models of pulmonary hypertension, including transgenic VIP/ mice, adiponectin (APN) deficient mice, IL-6 transgenic mice, and the BMPR2 mutated mouse model all exhibit perivascular accumulation of leukocytes.

 

Additional keywords: leukocyte,macrophages

Science that starts with a hello.

Through global collaboration, we make today's work, tomorrow's possibility.

Join the PVRI
standard-example-image.jpg