Changes in PVR and mPAP with inhaled NO and O2 predict survival across multiple subpopulations of PAH. Forest plots of age-adjusted Cox proportional hazard ratios are depicted on a logarithmic scale, with ratios less than 1 indicating a favorable prognosis with vasoreactivity to inhaled NO and O2. In (A), vasoreactivity is defined as a30% decrease in PVR with vasodilator compared to baseline. In (B), vasoreactivity is defined as a12% decrease in mPAP with vasodilator compared to baseline. * indicates vasodilator non-responsiveness by current guidelines.[3,4] indicates PAH associated with collagen vascular disease (CVD), portal hypertension, congenital heart disease, HIV, anorexigen use, or Gaucher's disease.
Additional keywords: NO,nitric oxide,gender,age,groups