01 January 2015 by Aaron Waxman, Marc Semigran

Changes in PVR and mPAP with inhaled NO and O2 predict survival across multiple subpopulations of PAH

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Semigran {MJ},Hess D,Bloch {KD},Malhotra R,Lewis {GD},Waxman {AB}.Vasoreactivity to inhaled nitric oxide with oxygen predicts long-term survival in pulmonary arterial hypertension. [Internet]. 2011 ;1:250. Available from:http://www.pulmonarycirculation.org/text.asp?2011/1/2/250/83449

Changes in PVR and mPAP with inhaled NO and O2 predict survival across multiple subpopulations of PAH. Forest plots of age-adjusted Cox proportional hazard ratios are depicted on a logarithmic scale, with ratios less than 1 indicating a favorable prognosis with vasoreactivity to inhaled NO and O2. In (A), vasoreactivity is defined as a30% decrease in PVR with vasodilator compared to baseline. In (B), vasoreactivity is defined as a12% decrease in mPAP with vasodilator compared to baseline. * indicates vasodilator non-responsiveness by current guidelines.[3,4] indicates PAH associated with collagen vascular disease (CVD), portal hypertension, congenital heart disease, HIV, anorexigen use, or Gaucher's disease.

 

Additional keywords: NO,nitric oxide,gender,age,groups

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