DNA methyltransferase expression is increased in FHR lung and PASMCs. (a) DNA MT1 and 3B mRNA are increased in FHR vs SDR lungs (n=12 each). *P<0.05, **P<0.01. (b) In low-passage (3 to 4) PASMCs (n=8 in each group), FHRs had higher DNA MT3B expression and a trend toward increased DNA MT1. Reproduced with permission from Archer et al.Black bars = FHR; White bars = SDR ;(1) Archer SL,Marsboom G,Kim GH,Zhang HJ,Toth PT,Svensson EC,Dyck JRB,Gomberg-Maitland M,Thbaud B,Husain AN, et al.Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target.Circulation. 2010 ;121(24):2661-71.
Additional keywords: methyltransferase,DNA,PASMC,fawn hooded rat,smooth muscle cell