01 January 2015

HistoneDNA complexes are released from leukocytes and activate platelets by binding to their tolllike receptors TLR2 and TLR4

AI00008.jpg
Kroll {MH},Afshar-Kharghan V.Platelets in pulmonary vascular physiology and pathology. [Internet]. 2012 ;2:291. Available from:http://www.pulmonarycirculation.org/text.asp?2012/2/3/291/101398

HistoneDNA complexes are released from leukocytes and activate platelets by binding to their tolllike receptors TLR2 and TLR4. Activated or apoptotic neutrophils release histones that bind to specific platelet tolllike receptors. This results in platelet activation leading to several important antimicrobial, proinflammatory, and prothrombotic responses, including the secretion of platelet microbicidal proteins, Pselectin expression, platelet aggregation, and the expression on the platelet surface of prothrombinase activity leading to fibrin production and deposition. This figure was originally published in Blood by the American Society of Hematology (ASH). Inflammation and the platelet histone trap by Lea M. Beaulieu and Jane E. Freedman in Blood 2011;118:17141715. 2012 Reproduced with permission of ASH in the format republish in a journal via Copyright Clearance Center

 

Additional keywords: thrombosis,thrombus,immunology,toll like receptor,Histone

Science that starts with a hello.

Through global collaboration, we make today's work, tomorrow's possibility.

Join the PVRI
standard-example-image.jpg