Hypoxia-induced pulmonary remodeling is characterized by monocyte/fi brocyte accumulation in the adventitia and media. (a) Sustained hypoxia induces a robust appearance of mononuclear CD45+ cells (indirectly labeled with red fl uorochrome) in the pulmonary arterial adventitia (these lesions are marked by triple large arrowheads in the 'Hypoxia' columns). (b) A large proportion (around 40%) of the CD45 + leukocytic cells (red fl uorescence) accumulating in the remodeled pulmonary arterial adventitia of hypoxic hypertensive calves co-express type 1 pro-collagen (green fl uorescence), suggestive of a fi brocyte phenotype. Scale bars, 5 m. (Adapted from: Frid et al.).
Additional keywords: monocytes,fibrocyte,adventitia,media