01 January 2015 by Bhola Kumar Dahal, Norbert Weissmann, Werner Seeger, Friedrich Grimminger, Ralph T. Schermuly

Localization of stromal cell derived factor (SDF)-1, CXCR4 and PDGFR- in lungs from IPAH patients

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Schermuly {RT},Dahal {BK},Pullamsetti {SS},Ghofrani {HA},Seeger W,Heuchel R,Wilhelm J,Weissmann N,Grimminger F.Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-. [Internet]. 2011 ;1:259. Available from:http://www.pulmonarycirculation.org/text.asp?2011/1/2/259/83448

Localization of stromal cell derived factor (SDF)-1, CXCR4 and PDGFR- in lungs from IPAH patients. By immunohistochemistry, the localization of SDF-1, CXCR4 and PDGFR- was performed on serial sections of lung tissues from donors and patients with IPAH (n=4). The brown staining (arrow) represents the positive immunoreactive signal for the SDF-1, CXCR4 and PDGFR-. The lung tissues were also stained for a-SMC actin (purple color, arrow head). In addition, negative control staining was performed by using blocking solution instead of the primary antibody. Representative photomicrographs of immunostained and the negative control staining of the lung sections from donor and patients with IPAH are shown. V Vessel, Scale=20 mm.

 

Additional keywords: imatinib,mouse,PDGF,CXCR,stromal

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