01 January 2015 by Michael Yeager, Kurt R Stenmark

Potential origins of fi broblasts / myofi broblasts in the vessel wall

Yeager ME,Frid MG,Stenmark KR.Progenitor cells in pulmonary vascular remodeling. [Internet]. 2011 ;1:3. Available from:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198626/

Potential origins of fi broblasts / myofi broblasts in the vessel wall. Several potential origins for tissue myofi broblasts have been proposed: (1) In several organs, -SMA-expressing myofi broblasts are believed to originate from tissue-resident fi broblasts; (2) In the vasculature, myofi broblasts may arise through de-differentiation of resident SMC; (3) Epithelial cells can give rise to fi broblasts / myofi broblasts in the lung and other organs through a process of endothelial-mesenchymal transdifferentiation (EMT); (4) In the lung, endothelial-to-mesenchymal (EnMT) transition may provide another mechanism to generate myofibroblasts; (5) In various fi brotic lesions in tissue injury/ repair processes, bone marrow-derived circulating progenitor cells are proposed, to contribute to the pool of myofi broblasts (Adapted from Hinz et al.)


Additional keywords: fibroblast,myofibroblast,differentiation,epithelium

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