01 January 2015

Receptor tyrosine kinase (RTK) signaling

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Schermuly {RT},Pullamsetti {SS}.Receptor tyrosine kinases in pulmonary hypertension. [Internet]. 2009 ;1:124. Available from:http://www.pvrireview.org/text.asp?2009/1/2/124/50732

Receptor tyrosine kinase (RTK) signaling: Upon ligand binding and activation, the intracellular catalytic domain of RTKs catalyzes receptor autophosphorylation of cytoplasmic tyrosine residues serving as docking sites for (SH)2- and phosphotyrosine-binding (PTB)-containing molecules. Assembly of activated protein complexes triggers signaling cascades that can activate or repress genes involved in cell growth, proliferation, differentiation and survival. Abbreviations: P, phosphorylated tyrosine residue; PI3K, phosphatidylinositol 3-kinase; Pdk1, phosphoinositide-dependent protein kinase-1; Akt, oncogenic kinase initially isolated from a transforming mouse retrovirus; PLC, phospholipase C; PKC, protein kinase C; Src, oncogene of the chicken Rous sarcoma virus, Sos, (son of sevenless); Grb2, (growth factor receptor-bound protein 2) are adaptor proteins; Ras, oncogene fi rst isolated in rat sarcomas; Raf, oncogenic kinase initially isolated from a transforming mouse virus; ERK, extracellular-regulated kinase; JAK, Janus kinase; STAT, signal transducer and activator of transcription.

 

Additional keywords: tyrosine kinase inhibitor,survival,proliferation,migration,RTK

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