01 January 2015 by Jason Yuan

Representative Photomicrographs of Peripheral Lung Tissue

Below are eight figures: 4 from a normal control lung (A and B) and four from a patient (C-H) with pulmonary arterial hypertension (PAH).

Yuan {JX-J},Firth {AL}.Identification of functional progenitor cells in the pulmonary vasculature. [Internet]. 2012 ;2:84. Available from:http://www.pulmonarycirculation.org/text.asp?2012/2/1/84/94841


A short rundown of the methodology and results of representative photomicrographs of peripheral lung tissue from (A and B) normal control lung and (C-H) a patient with pulmonary arterial hypertension (PAH):

  1. Samples were immunostained for CXCR4 and stromal-cell-derived factor (SDF)-1. Minimal staining is seen in the normal lung (C and D).


  1. In PAH lung low-level staining was observed in concentric intimal lesions. (E and G) CXCR4 expression was generally increased in the lung parenchyma of patients with pulmonary arterial hypertension, but was also present in the endothelium of plexiform lesions.


  1. (F and H) SDF-1 was less prevalent but showed clear staining of the endothelium of plexiform lesions. Scale bars: 50 m.


Additional keywords: plexiform lesion, lesions, media, intima, progenitor cell

About the author

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Jason Yuan

Editor in Cheif of Pulmonary Circulation and Professor at

University of California San Diego

United States

"2019 has been another great year for Pulmonary Circulation. We continue to see increasing numbers of articles submitted and now receive many good quality papers. We have been able to raise the bar for acceptance and we are pleased to say that it is now becoming more difficult to get published in Pulmonary Circulation!"

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