01 January 2015 by Bhola Kumar Dahal, Norbert Weissmann, Werner Seeger, Ralph T. Schermuly

Right ventricular hypertrophy in hypoxic mutant (D849N) mice receiving imatinib

Schermuly {RT},Dahal {BK},Pullamsetti {SS},Ghofrani {HA},Seeger W,Heuchel R,Wilhelm J,Weissmann N,Grimminger F.Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-. [Internet]. 2011 ;1:259. Available from:http://www.pulmonarycirculation.org/text.asp?2011/1/2/259/83448

Right ventricular hypertrophy in hypoxic mutant (D849N) mice receiving imatinib. Wild type and D849N mice were exposed to hypoxia for 35 days or remained in normoxia throughout (normoxic control). Hypoxic mice (n=10) received imatinib orally by gavage from day 21 to day 35 at a dose of 100 mg kg 1 BW. Hypoxic control animals received placebo (n=10). (a) RV/(LV+S) and (b) RV/BW (in mg/g) of different experimental groups are shown. Each bar represents meanSEM. *P<0.05 vs. normoxic control; P<0.05 vs. corresponding hypoxic control.


Additional keywords: imatinib,mouse,PDGF,fulton index

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