01 January 2015

The thrombopoietic agent romiplostim induces an increase in megakaryocytes in the lungs of mice

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Kroll {MH},Afshar-Kharghan V.Platelets in pulmonary vascular physiology and pathology. [Internet]. 2012 ;2:291. Available from:http://www.pulmonarycirculation.org/text.asp?2012/2/3/291/101398

The thrombopoietic agent romiplostim induces an increase in megakaryocytes in the lungs of mice. (A) H and Estained lung tissue of a normal mouse animal treated with romiplostim showing a representative lung megakaryocyte embolus (arrow). (B) Quantification of the emboli per capillary in lung tissue. Each bar represents the mean SEM of 10 animals. This figure was originally published in Blood by the American Society of Hematology (ASH). Romiplostim administration shows reduced megakaryocyte response capacity and increased myelofibrosis in a mouse model of MYH9RD by Catherine Leon, Katja Evert, Frank Dombrowski, Fabien Pertuy, Anita Eckly, Patricia Laeuffer, Christian Gachet, and Andreas Greinacher in Blood 2012;119:33333341. 2012 Reproduced with permission of ASH in the format republish in a journal via Copyright Clearance Center

 

Additional keywords: megakaryocytes,romiplostim,immunology,emboli,thrombus

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