Vasa vasorum expansion in the hypoxic calf model of pulmonary hypertension and in iPAH. (A) In both large (panels A and C) and small pulmonary arteries (panels B and D) of the chronically hypoxic calf, marked expansion of the vasa vasorum is observed. Panels A and B demonstrate H and E staining. Panels C and D demonstrate von Willebrand Factor expression. (B) In pulmonary arterial lesions of patients with iPAH a large expansion of CD34+ vasa vasorum vessels around the remodeled pulmonary arteries is observed (panels B, C, and D). Rare CD 34+ vessels around pulmonary arteries of control subjects are observed (panel A).
Additional keywords: calf,vaso vasorum