01 January 2015 by Kurt R Stenmark, Michael Yeager

Vasa vasorum expansion in the hypoxic calf model of pulmonary hypertension and in iPAH

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Stenmark {KR},Yeager M,Riddle S,El Kasmi {KC},Frid {MG},Li M,{McKinsey} T.Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change. [Internet]. 2012 ;2:3. Available from:http://www.pulmonarycirculation.org/text.asp?2012/2/1/3/94817

Vasa vasorum expansion in the hypoxic calf model of pulmonary hypertension and in iPAH. (A) In both large (panels A and C) and small pulmonary arteries (panels B and D) of the chronically hypoxic calf, marked expansion of the vasa vasorum is observed. Panels A and B demonstrate H and E staining. Panels C and D demonstrate von Willebrand Factor expression. (B) In pulmonary arterial lesions of patients with iPAH a large expansion of CD34+ vasa vasorum vessels around the remodeled pulmonary arteries is observed (panels B, C, and D). Rare CD 34+ vessels around pulmonary arteries of control subjects are observed (panel A).

 

Additional keywords: calf,vaso vasorum

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