The effect of altitude is significant over 2.500 MOSL. Bogotá, where we made the study, is at 2.640 MOSL.
To show the effect of hypobaric hypoxia on PH in Children.
We included new patients studied the last 12 months. All had clinical evaluation, BNP, hyperoxia test and catheterism. One patient did not have catheterism because he died before the procedure. Necropsy showed IPH with severe PVD. All patients had prolonged hyperoxia test and VRT with NO and oxygen. Living at low altitude was recommended.
We had 20 new patients; 16 females (80%); 8 were 3 years old or less (40%); 12 had IPH (60%), 4 CHD (3 developed PH after surgery); 2 CPD, 1 HAPE and 1 group 5. Majority of patients had severe PH: MPP >60 mm Hg; PR >20WU.
Altitude gives special characteristics to PH by hypobaric hypoxia, affecting epidemiology, pathogenesis, diagnostic approach and treatment. Epidemiology: PH is frequent, begins and could be severe at an early age, and IPH is the main cause. Pathogenesis: Hyperreactivity of PV is important and remodeling could be severe very early. Diagnosis and treatment: Oxygen plays important role.
At altitude, Hypobaric Hypoxia gives special characteristics to PH. Because Hypobaric Hypoxia influences not only other pathologies of group 3 but also pathologies of groups 1 and 5 of Nice Classification, maybe PH of altitude deserve to be considered as a subgroup of group 3