07 February 2017 by edward k weir, Wiltz Wagner

The Pulmonary Circulation and Gas Exchange

Twice a month, we'll be releasing a chapter of "The Pulmonary Circulation and Gas Exchange" edited by Wiltz W. Wagner, Jr., PhD, and E. Kenneth Weir, MD, and first published in 1994.

In this volume, the evolution of our current understanding of a number of areas of pulmonary function, both the physiology and the pathophysiology, are explained. The authors were specifically instructed to write in plain English and not to obfuscate the material with equations. This elite group of scientists succeeded brilliantly.

Subjects that are often difficult to understand such as the diffusion of gases are lucidly explained-not only the physiology of the subject, but the clinical areas when the gas exchange properties of the lung go awry.

How the pulmonary circulation is remodeled in disease is laid out by the scientists who did the original work. Their difficulties and disagreements are discussed in a way that leaves readers in a position to make up their own minds.

The fascinating area of high altitude physiology and medicine is described by the men and women who did the basic work. This area of research has always been interesting not only because of the inherent nature of the subject, but also because it serves as a good model for many lung diseases.

The complex work on the relationships of pressure and flow in health and disease are explored. Pulmonary pharmacology, the anatomy of the pulmonary blood vessels, and alterations in the pulmonary circulation in relationship to respiration and in disease are all brought into sharp focus by the masters of these fields.

In addition to being a repository for considerable scientific information, the autobiographic details are filled with anecdotes that are sometimes amusing, sometimes touching, and always interesting.

The editors gratefully acknowledge Cathy Kreyche and Linda Shaw who provided invaluable editorial expertise and James A. Will who provided some of the photographs of the contributors.

Wiltz W. Wagner, Jr.

E. Kenneth Weir

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Table of contents

  1. Strength and Failure of Pulmonary Capillaries, John B. West, M.D., Ph.D., D.Sc.
  2. Exploring the Structural Basis for Pulmonary Gas Exchange, Edwald R. Weibel, M.D.
  3. Pulmonary Vascular Disease: A Joint Adventure, C. A. Wagenvoort, M.D.
  4. Pulmonary Edema: Then and Now, Norman C. Staub, M.D.
  5. Structural Remodeling of the Pulmonary Vasculature by Environmental Change and Disease, Lynne M. Reid, M.D.
  6. A Personal View of Neonatal Pulmonary Hypertension, John T. Reeves, M.D.
  7. Search for Diffusion Limitation in Pulmonary Gas Exchange, Johannes Piiper, M.D.
  8. Pulmonary Mechanics and the Pulmonary Blood Vessels, Solbert Permutt, M.D.
  9. Encounters with the Pulmonary Circulation, Thomas C. Lloyd, M.D.
  10. My Studies of the Lung Microcirculation, Grant de J. Lee, M.D.
  11. Adventures in Gas Exchange, Robert L. Johnson, M.D.
  12. An Approach to the Study of the Pulmonary Circulation, Albert L. Hyman, M.D.
  13. The Pulmonary Vascular Tree Seen as a Convergent Tree, Keith Horsfield, M.D.
  14. Pulmonary Vascular Disease in Sheffield, the Andes, Tibet, and Tanzania, Donald Heath, D.Sc., M.D., Ph.D.
  15. The Pulmonary Circulation of Some Domestic Animals at High Altitude: The Real Story, Peter Harris, M.D., Ph.D.
  16. Pulmonary Hypertension: The Price of High Living, Robert F. Grover, M.D., Ph.D.
  17. Pressure, Flow, Stress, and Remodeling in the Pulmonary Vasculature, Yuan-Cheng B. Fung, Ph.D.
  18. The Exotic Gases, CO, 02, and CO2, Robert E. Forster, M.D.
  19. A Physician-Scientist's Tale, Alfred P. Fishman, M.D.
  20. Reflections on the Waterfall in the Chest, John Butler, M.D.
  21. Acute and Chronic Lack of Oxygen: Consequences for the Lung and Carotid Body; A Journey with Bacillus Investigationis, the Curiosity Bug, Gwenda R. Barer, M.D.

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