01 March 2017 by Mehmet Serdar Kucukoglu

Evaluation of health-related quality life in patients with pulmonary arterial hypertension

Various health-related quality of life  (HRQoL) instruments have been employed to measure the effects of pulmonary arterial hypertension (PAH).  The aim of this study was to evaluate the HRQoL with the generic and the disease specific HRQoL instrument in patients with PAH.

Thirty  patients (mean age 39.3±10.7 yrs) were enrolled for the study. All patients completed the generic Medical Outcomes Study Short-Form 36 (SF-36) and the disease-specific Minnesota Living With Heart Failure Questionnaire (MLWHFQ) to measure HRQoL.  The SF-36 contains 8 subscales; physical functioning (PF), role physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MH) and 2 summary scores; physical component summary (PCS) and mental component summary (MCS). The MLWHFQ  is divided into three separate scores; physical, emotional and total scores.

MLWHFQ physical, emotional, and total scores were negatively correlated with all subscale and all summary scores of SF-36. Total scores were correlated with PF: r=-0.60; p=0.0005, RP: r=-0.66; p<0.0001, BP: r=-0.72; p<0.0001, GH: r=-0.67; p<0.0001, VT: r=-0.67; p<0.0001, SF: r=-0.61; p=0.003, RE: r=-046; p=0.01, MH: r=-0.59; p=0.0006 and PCS: r=-0.66; p<0.0001, MCS: r=-0.46; p=0.01.

In conclusion, both SF-36 and MLWHFQ can be used to assess HRQL in PAH.

Key Contributors

Rengin Demir, Ümit Yaşar Sinan, M. Serdar Küçükoğlu* Istanbul University Institute of Cardiology, Cardiology Department; Istanbul, Turkey

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