20 February 2018 by Ergun Baris Kaya

Clinical characteristics, survival analysis and mortality predictors of patients with chronic thromboembolic pulmonary hypertension: a single center experience

Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the leading causes of pulmonary hypertension. The aim of the study was to investigate clinical and laboratory datas, yearly survival rates and mortality predictors of patients with CTEPH.

Methods

Patients with pulmonary hypertension were screened from the electronic data base and 22 cases who were diagnosed CTEPH were included to the study. Patients baseline characteristics, comorbidities, medications, echocardiography, right heart catheterization and laboratory parameters (B-type natriuretic peptide, hemoglobin level, time in therapeutic range-TTR), and mortality datas were recorded.

Results

22 patients (14 female and 8 male, median age: 52.5 years) were included to the study. Median follow time was 1.38 (0.05-6.19) years. One-year survival rate was 81% and 3-year survival rate was calculated as 68%. Univariate cox regression analysis revealed that BNP, TTR, gender, smoking and right ventricular end-diastolic diameter (EDD) were associated with mortality. Right ventricular EDD was significantly smaller in survival patients than without. We performed multivariate Cox regression analysis using covariates that showed significance in the univariate analysis. Gender and right ventricular EDD were established as the best predictors of mortality (Gender: odds ratio 0.021, CI 0.001-0.645, p=0.027 and right ventricular EDV: odds ratio 50.740, CI 1.207-2133.0, p= 0.040).

Conclusions

In this study including limited number of patients with CTEPH, we found gender and right ventricular EDV as a predictor of long-term mortality. These findings should be confirmed by prospective studies with more patients.

About the author


profile picture of Ergun Baris Kaya

Ergun Baris Kaya

prof. dr. md

hacettepe university faculty of medicine cardiology department

Turkey

Key Contributors

Ergün Barış Kaya(1), Yusuf Ziya Şener(1), Metin Okşul(1), Levent Şahiner(1), Ali AkdoğanA(2), Lale Tokgözoğlu(1) 1. Hacettepe University Faculty of Medicine Cardiology Department 2. Hacettepe University Faculty of Medicine Rheumatology Department


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