04 February 2019 by Jeisson Osorio Trujillo

Heterogeneity in lung 18F-FDG uptake in precapillary pulmonary hypertension


Proliferative changes in pulmonary vessels may contribute to the development of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Previous studies using [18F]-fluoro-D-glucose positron emission tomography (PET-FDG) imaging in PAH have shown increased cellular metabolism in right ventricle (RV), while the results of uptake in pulmonary artery (PA) and lung parenchyma (LP) are contradictory.The present study aimed to evaluate cellular metabolism in LP, PA and RV by means of PET-FDG in patients with PAH or CTPEH, compared to healthy subjects.


Four groups were evaluated: Healthy controls, n=20; idiopathic PAH (iPAH), n=20; proximal CTEPH (CTEPH-p), n=15; and distal CTEPH (CTEPH-d), n=10. The mean values of standardized 18F-FDG uptake of predefined regions of interest in LP (7 planes per lung in defined anatomical points), PA, RV and left ventricle (LV), were. SUV ratios in patients were related to functional class (FC), exercise tolerance, hemodynamic parameters and serum BNP.

Results and conclusions

The results are shown in Table 1. The RV/LV ratio and AP uptake were significantly correlated with the BNP. AP uptake was correlated with the walking test.
We conclude that patients with precapillary pulmonary hypertension show increased FDG uptake in the right ventricle, particularly those with iPAH. The FDG uptake in both parenchyma and pulmonary arteries were significantly higher in the group with distal CTEPH.


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About the author

profile picture of Jeisson Osorio Trujillo

Jeisson Osorio Trujillo


Hospital Clínic of Barcelona


Key Contributors

Jeisson Osorio 1, Olga Tura-Ceide 1, Javier Pavia 2, Eduard Agustí-Camprubí 2, Iván Vollmer 2, Isabel Blanco 1, Jesús Ruiz-Cabello 3, Samuel España 4, Manel Castellà 5, Yolanda Torralba 1, Laura Sebastián 1, Lucilla Piccari 1, Cristina Bonjoch 1, Víctor Peinado 1, Joan Albert Barberà 1. 1 Department of Pulmonary Medicine, Hospital Clínic-IDIBAPS, University of Barcelona; Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain; 2 Center for Diagnostic Imaging, Hospital Clínic-IDIBAPS, University of Barcelona, 3 Biomedical Research Networking Center on Respiratory Diseases (CIBERES); Completes University of Madrid, Spain; 4 National Center for Cardiovascular Research (CNIC), Madrid, Spain; 5 Department of Cardiovascular Surgery, Hospital Clínic-IDIBAPS, University of Barcelona, Spain.

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