15 February 2020 by Maria Coronel

Assessment of functional capacity in chronic thromboembolic pulmonary hypertension after pulmonary endarterectomy.

Pathophysiology of chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by thrombotic lesions at pulmonary arteries and arteriolar remodeling in distal regions. There is an increase in pulmonary vascular resistance that will lead to heart failure and early death without treatment. Currently, pulmonary endarterectomy (PE) is the potentially curative treatment for this condition. Cardiopulmonary exercise test(CPET) allows to quantify functional improvement after PE.

Objective: To analyze changes in CPET and hemodynamic parameters after surgery in a cohort of patients with CTEPH.

Methods: 502 patients with CTEPH have been evaluated until December 2018, PE was performed in 255 (51%). In 49 patients, CPET was available before and 6 months after surgery. Residual pulmonary hypertension (RPH) was defined as mean pulmonary arterial pressure ≥30 mmHg evaluated by right cardiac catheterization at 3-6 months after PE.

Results: 54% were men, mean age 48± 13years. Two thirds of patients were in functional class II/III at time of diagnosis and with severe hemodynamic and functional profile. Hemodynamics and CPET parameters improved after surgery. However, in patients with RPH they did not improve significantly. Results are shown in table

Conclusions: PE restores functional capacity in CTEPH, represented by significant improvement in CPET parameters. CPET is emerging as a non-invasive technique suitable of detecting RPH. More studies are needed to confirm this hypothesis. (for full results table see 'CTA - view full pdf')

Key Contributors

María Lorena Coronel, Ángela Flox Camacho, Teresa Segura De La Cal, Carmen Perez Olivares Delgado, María José Cristo Ropero, Jorge Nuche Berenguer, Mª Teresa Velázquez Martín, María Jesús López Gude, M. Pilar Escribano Subias Hospital Universitario 12 de Octubre, Madrid


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