27 January 2016

Postdoc position at the NIH

Postdoc position in Bethesda is closing soon

Job Description: Pulmonary arterial hypertension (PAH) is a rare disorder associated with poor survival. Endothelial dysfunction resulting from 1) genetic susceptibility and 2) triggering stimuli that initiate pulmonary vascular inflammation, injury and pathologic remodeling play a central role in the pathogenesis and progression of PAH.

Job Description

Pulmonary arterial hypertension (PAH) is a rare disorder associated with poor survival. Endothelial dysfunction resulting from 1) genetic susceptibility and 2) triggering stimuli that initiate pulmonary vascular inflammation, injury and pathologic remodeling play a central role in the pathogenesis and progression of PAH. Loss-of-function mutations in bone morphogenetic protein receptor-2 (BMPR2), a member of the TGF-β superfamily, are the most common cause of heritable PAH. BMPR2 silencing in human pulmonary artery endothelial cells reproduced many of the phenotypic abnormalities associated with PAH in vivo, including proliferation, hyper-motility and a disrupted cytoskeletal architecture.

Job Description

Pulmonary arterial hypertension (PAH) is a rare disorder associated with poor survival. Endothelial dysfunction resulting from 1) genetic susceptibility and 2) triggering stimuli that initiate pulmonary vascular inflammation, injury and pathologic remodeling play a central role in the pathogenesis and progression of PAH. Loss-of-function mutations in bone morphogenetic protein receptor-2 (BMPR2), a member of the TGF-β superfamily, are the most common cause of heritable PAH. BMPR2 silencing in human pulmonary artery endothelial cells reproduced many of the phenotypic abnormalities associated with PAH in vivo, including proliferation, hyper-motility and a disrupted cytoskeletal architecture.


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