01 April 2019

PVRI Jobs Board: March

Lecturer in Cardiopulmonary Sciences, University of Sheffield, UK

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The University of Sheffield are seeking a lecturer who has either a strong track record in functional genomics/applied bioinformatics with broad experience in genetics, clinical bioinformatics and next generation sequencing analysis, or applied translational biomedical science using in vitro and in vivo models. In either case, you must be familiar with the application of your skills to produce translationally focused research outputs. 

You will be responsible for the development of a high-quality research programme which attracts external research funding and delivers high quality scientific discoveries and published outputs. You will have a PhD (or equivalent higher degree) in the area of cardiopulmonary physiology, molecular biology, computer science, bioinformatics, biomedical engineering, or another relevant field with a computational component.  You will also have significant post-doctoral experience in cardiovascular biology, functional genomics or experience in analysing datasets from genomics, epigenomics, transcriptomics, proteomics and metabolomics.

Alan Lawrie & Andrew Swift

You will work alongside Prof Allan Lawrie (https://www.sheffield.ac.uk/iicd/profiles/lawrie) and join the Pulmonary Vascular Research group in the Department of Infection, Immunity & Cardiovascular Disease (IICD) (http://www.sheffield.ac.uk/cardiovascularscience/index) within the Faculty of Medicine, Dentistry and Health, and the Donald Heath Research Programme in Pulmonary Hypertension Research. The Donald Heath research programme in PH (https://donaldheath.org) was founded in 2015 and is built upon strong collaborative links between Professor David Kiely (Sheffield Pulmonary Vascular Disease Unit Director), Professor Allan Lawrie (British Heart Foundation Senior Basic Science Research Fellow) and Professor Jim Wild (National Institute for Health Research Professor) which has driven forward the growth of PH research in Sheffield over the past 15 years.

Post Doctoral Fellow, National Institute of Health, Bethesda, USA

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Pulmonary arterial hypertension (PAH) is a rare, female predominant, progressive disease characterized by vascular cell proliferation and infiltration of activated inflammatory cells leading to the progressive narrowing and even obliteration of distal pulmonary arteries. Loss of vascular cross-sectional area leads to progressive increases in pulmonary vascular resistance that eventually overwhelms right ventricular (RV) adaptation, resulting in RV failure and death. With the advent of semi-selective pulmonary vasodilator therapy, outcomes for PAH patients have improved, but mortality remains unacceptably high.

Despite clinical associations of PAH with autoimmunity, infection, and both local and systemic immune activation in patients, the consequences of PAH-associated genetic defects on immune function and activation is largely unknown. Building upon our work in human pulmonary artery endothelial cells, we are now examining the impact of PAH-associated genetic defects on immune effector cells. The overall goal of this project is to develop in vitro models of PAH immunopathobiology that enable identification of promising molecular targets. Murine models of PAH genetic susceptibility will also be utilized to investigate molecular mechanisms identified in vitro. 

The SU-5416/hypoxia rat model of PAH is available for the preclinical testing of therapeutic approaches arising from the basic science laboratory. An active clinical research program in PAH within the department also provides access to patient samples and a pathway for future clinical trials. 

Qualifications: Applicants must have the following: Ph.D. degree in the Biological Sciences, conferred within the last five years, with an interest in translational research related to vascular biology and inflammation.Qualified candidates should have direct experience with many of the following laboratory techniques:Cell culture, cell transfection, quantitative real-time PCR, Western blotting, flow cytometry, maintaining rodent colonies including breeding and genotyping of transgenic mice, and ELISA. Expertise in flow cytometry and confocal microscopy would be highly valued. The candidate is expected toconduct semi-independent research and function as part of a team. A strong background in immunology and molecular biology is required. Previous experience in pulmonary vascular biology is highly desirable. 

To Apply: Please send a cover letter, a CV including bibliography, and the names and contact information for three references to Jason Elinoff, MD, Tenure-Track Investigator, elinoffj@cc.nih.gov.

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