Different HDAC activity in several PH-animal models

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Essential differences are found in HDAC activity between heart and lung, Because lung HDAC activity is decreased in several experimental PH models, remodeling of the pulmonary vascular vessel seems not to require a continued increase in HDAC activity. RV HDAC activity was increased in several models of RV hypertrophy, which suggests that HDAC activity plays an important role in the compensation to pressure overload. THe clinical implications of our findings is that the effects of HDAC inhibitors in humans with PAH are unpredictable and may include RV functional deterioration, especially when a reduction in pulmonary vascular resistance is not feasible.


Animal Models
Pharmacology: Pharmacokinetics and Pharmacodynamics
Pulmonary Arterial Hypertension
Right Ventricle: Structure, Function and Dysfunction

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PVRI Chronicle Vol 1: Issue 2 cover image

December 2014

PVRI Chronicle Vol 1: Issue 2

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