Learning and research

Leading researchers showcase cutting-edge bioengineering and bioprinting technologies — from organ-on-a-chip models to 3D-printed vasculature — driving new insights into pulmonary hypertension mechanisms and therapies.

In this Living Legends in PH session, Rubin Tuder reflects on a career that has shaped modern pulmonary hypertension research. He discusses key scientific advances, including the Sugen–hypoxia rat model, and shares personal insights on discovery, mentorship, and the evolution of the PH field, joined by Paul Hassoun and Jason Hong.

This PVRI Digital Webinar is part of the 'Living Legends in PH: History & Personal Perspectives' session. Features:

• Living Legend: Lewis Rubin, University of California San Diego
• Senior facilitator: Jason Yuan, University of Florida 
• Junior facilitator: Jose Gomez-Arroyo, University of Cincinnati

Webinar presentations: Cardiopulmonary networks: bridging infection and microbiome in pulmonary vascular disease; Inflammasome activation in pulmonary arterial hypertension; Role of oxidative signals in endothelial phenotypes in PH; Spironolactone: an old drug with new tricks; HIPPO/MST signaling via BUB3 and FOXO drives pulmonary vascular cell growth and survival
 

Webinar presentations: Hispanic ethnicity and social determinants of health in pulmonary arterial hypertension; Sirtuin 3 and uncoupling protein2, the missing link between genetics, metabolism, and pulmonary arterial hypertension; Estrogen and portopulmonary hypertension: the Pulmonary Vascular Complications of Liver Disease Study; The right heart network and risk stratification in pulmonary arterial hypertension; Pulmonary hypertension caused by autocrine endothelial signaling
 

Webinar presentations: The PAH microenvironment: lessons learned from tumor microenvironment mechano-induced cell metabolism changes; Identification of arterial and venous morphologic markers in pulmonary arterial hypertension using CT imaging; The keto diet as treatment for pulmonary hypertension associated with obesity; Endothelial transdifferential from exacerbated inflammatory signaling in BMP9 in lung endothelium; The role of pericytes in the pathophysiology of pulmonary arterial hypertension

Webinar presentations: Cellular mechosignaling in pulmonary arterial hypertension; Sex differences in pulmonary arterial hypertension randomized clinical trials; Precapillary pulmonary hypertension and death from COVID-19; Estradiol and estrogen receptor protection of right ventricular function – role of apelin; Prostacyclin reverses right ventricular hypertrophy and dysfunction in severe PAH; Pulmonary vascular complications of heart failure with preserved ejection fraction

Webinar presentations: Autophagy and BMPR2 receptor degradation as the cause of PAH; BMPR1A promotes ID2-ZEB1 interaction to suppress endothelial to mesenchymal transition in PAH; Cardiovascular and pulmonary phenotypes for single and double knockout mice deficient in BMP9 and BMP10; BMPR2 – When and where the animal models match patient disease