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In this Call, Dr. Tyler Couch discusses using chest CT to assess pulmonary artery dilation across chronic lung diseases and its correlation with PH. Dr. Agustin Garcia Roca details how CT vessel metrics characterise pulmonary vascular abnormalities and severe PH in COPD and fibrosing ILD. Dr. Olympia Bikou presents her study on microRNA-224 (miR-224) as a therapeutic target for PH, demonstrating its role in smooth muscle cell proliferation and the ameliorating effects of its inhibition on vascular remodelling and right heart function.

Invasive right heart catheterization (RHC) remains the reference standard for diagnosing pulmonary hypertension (PH), but there is a pressing need for non-invasive techniques to assess pulmonary hemodynamics. This study evaluates 4D-flow MRI-derived wall shear stress (WSS) for PH detection using the updated 2022 hemodynamic criteria, and the prediction of right ventriculo-pulmonary arterial (RV-PA) uncoupling to assess disease severity. 

Risk stratification is essential in pulmonary arterial hypertension (PAH), yet the prognostic utility of the albumin-bilirubin (ALBI) score as a marker of hepatic dysfunction remains underexplored. In this single-center study, we evaluated the clinical, neurohumoral, echocardiographic and hemodynamic correlates and prognostic value of the ALBI score, and to assess whether this score offers an incremental benefit over the Registry to EValuate Early And Long-term pulmonary arterial hypertension disease management (REVEAL) 2.0 risk score in patients with PAH.