Male Sex Is Associated With Severe Pulmonary Hypertension and Worse Outcome in Chronic Obstructive Pulmonary Disease Patients Referred for Right Heart Catheterization

31 March 2026

Katarina Zeder, Klemens Orasche, Teresa John, Philipp Douschan, Vasile Foris, Shelsey Johnson, Bradley A. Maron, Nikolaus Kneidinger, Gabor Kovacs

https://doi.org/10.1002/pul2.70233

 

Abstract

Sex differences in COPD patients with concomitant pulmonary hypertension remain unexplored. Analyzing 171 patients from the GRAPHIC registry in Graz, Austria, we found that male sex was independently associated with increased mortality risk, despite comparable comorbidities and airflow obstruction, which may be explained by the increased rate of severe PH.

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