Resting Oxygen Consumption Estimates in Scleroderma Can Lead to Underestimation of Cardiac Output

10 March 2026

Oscar Cullen, Laura Ross, Jessica L. Fairley, Luke W. Spencer, Amy M. Mitchell, Stephanie J. Rowe, Kristel Janssens, Youri Bekhuis, Stephen J. Foulkes, Paolo D'Ambrosio, Margarita Calvo-Lopez, Kaitlin Newcomb, Andre La Gerche, Andrew T. Burns

https://doi.org/10.1002/pul2.70280 

 

Abstract

Accurate resting oxygen consumption (rVO2) quantification is critical for Fick-derived cardiac output calculations. Yet, clinical practice predominantly uses empirical estimations, which can be inaccurate. We evaluated the established rVO₂ prediction equations against direct metabolic cart measurements in systemic sclerosis patients, revealing significant discordances with potential diagnostic implications.

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