Learning & research

In this PH Community Call, we discussed: 

• CES1 Deficiency is Associated With Metabolic Reprograming and Endothelial Dysfunction in Pulmonary Arterial Hypertension by Stuti Sunil Kumar Agarwal
• Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy by Madelyn Blake

Palliative care can be offered concurrently as a treatment option to patients with pulmonary arterial hypertension (PAH) to relieve symptoms and improve quality of life.

A 53-year-old woman with systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) presented with severe exertional desaturation, markedly reduced diffusing capacity (%DLCO 30%), and computed tomography findings demonstrating features of pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis (PVOD/PCH).

Right ventricular (RV) mechanical dyssynchrony represents a maladaptive response to increased afterload in pulmonary hypertension (PH). However, its hemodynamic and biochemical determinants remain unclear.

HIV-associated pulmonary arterial hypertension (HIV-PAH) remains one of the most consequential cardiopulmonary complications in people living with HIV (PLWH), persisting despite expanded antiretroviral therapy (ART) coverage.

Treprostinil palmitil (TP) inhalation powder (TPIP), an investigational formulation of the treprostinil prodrug TP, was designed to provide prolonged pulmonary vasodilation with once-daily administration. 

This study explored attitudes towards exercise, recollections of physical activity advice received, and the dimensions that influence physical activity (PA) engagement in individuals diagnosed with pulmonary hypertension. Virtual semi-structured interviews (n = 21) were conducted with those diagnosed with pulmonary hypertension. 

Group discussion session at Genetics-inspired Therapeutics for PH

Presented at Genetics-inspired Therapeutics for PH by Chris Rhodes, Imperial College London