The 2025 PVRI International Conference was held in Rio de Janeiro, Brazil under the theme “Embracing Heterogeneity” over 4 days of insightful discussions on pulmonary hypertension (PH). The conference covered a diverse array of topics spanning basic science, translational research, and clinical observations from around the world. Attendees included experts from backgrounds ranging from early-career investigators to senior scientists and clinicians and industry partners, representing 25 countries across 5 continents.