2025 Select Abstracts from the 18th Annual International Conference on Neonatal and Childhood Pulmonary Vascular Disease

The objective of this study is to assess the effect of subcutaneous treprostinil (TRE) administered peri-operatively after Fontan operation on chest tube duration (CTD), hospital length of stay (LOS), and post-operative hemodynamics. This is a single center randomized, blinded, placebo-controlled study of pediatric patients with single ventricle congenital heart disease undergoing Fontan operation between September 2015 and September 2019. 

As with adult pulmonary hypertension (PH), high morbidity and mortality persist with diverse types of paediatric PH. Despite major advances in pharmacologic therapies based on extensive studies in adult PH, few drugs have been comprehensively studied in neonates, infants, and children, leaving current paediatric PH care largely dependent on small observational studies and extrapolation of evidence from adult clinical trials.

Children with chronic diseases, including pulmonary hypertension (PH), have an increased risk of anxiety and depression (AD), impacting mental health (MH), and quality of life (QoL). We sought to characterize the prevalence of AD in pediatric PH and identify associated factors. We developed a prospective cross-sectional study with 10 Pediatric Pulmonary Hypertension Network (PPHNet) centers.

First approved by the US Food and Drug Administration in 2004, inhaled iloprost has become a mainstay of therapy for adults with pulmonary arterial hypertension (PAH) based on strong clinical trial evidence of its ability to improve symptoms and exercise capacity [1-3]. In 2023, however, the I-neb adaptive aerosol delivery system was discontinued, thereby limiting the availability of inhaled iloprost for new patients and promoting the ultimate discontinuation of the nebulized solution.