Early changes in the pulmonary vasculature in response to high altitude: mechanisms and potential treatments

Schistosomiasis-associated pulmonary arterial hypertension (Sch-PAH) is one of the most frequent etiologies of pulmonary arterial hypertension in Brazil and globally. The disease is a complication of hepatosplenic schistosomiasis characterized by portal hypertension, egg deposition, and granuloma formation in the pulmonary arteries leading to inflammation, vascular remodeling, increased pulmonary vascular resistance, and progressive right heart failure. 

Part of the 'Hypoxia in pulmonary vascular research – altitude and beyond' webinar series by the High Altitude Task Force, who raise awareness and understanding of PH linked to high altitude and organise scientific conferences in regions affected by high altitudes.

Presented at PVRI 2026 Congress by Tomas Pulido, Ignacio Chavez National Heart Institute

Presented at PVRI 2026 Congress by Roberto Bernardo, Stanford University