History of Adverse Pregnancy Outcomes in Women With Pulmonary Arterial Hypertension: A Single-Center Pilot Study

Pulmonary hypertension (PH) is defined hemodynamically as a mean pulmonary arterial pressure (mPAP) ≥ 20 mmHg, measured at right heart catheterization (RHC). Pulmonary arterial hypertension (PAH) is defined as a mPAP ≥ 20 mmHg with a pulmonary capillary wedge pressure (PCWP) or left ventricular end-diastolic pressure (LVEDP) of ≤ 15 mmHg and a pulmonary vascular resistance (PVR) > 2 Woods Units (WU). 

Pulmonary arterial hypertension (PAH) is a heterogenic diagnosis including idiopathic and hereditary PAH (IPAH/HPAH) and groups associated to connective tissue disease (APAH-CTD) and congenital heart disease (APAH-CHD). Pre- and post-diagnosis societal costs in PAH subgroups are not well known.

In this Community Call, we discussed: 

• Maternal outcomes among pregnant women with congenital heart disease–associated pulmonary hypertension
• Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension

Webinar presentations: Age-dependent prevalence of PH in the general population, Harm Jan Bogaard, Senescence mechanisms and pulmonary vascular aging, Serge Adnot, Metabolic Syndrome and obesity leads to age-related PH, Imad Al Ghouleh, Genetics and epigenetics in age-related PH, Stephen Archer, Right heart catheterization is underused in elderly patients suspected of pulmonary hypertension, Samara Jansen