Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis

22 December 2025

Claudia MickaelJane C. KabweDara Fonseca BalladaresAnnika S. BaiKevin NolanMichael H. LeeRahul KumarJoan F. HiltonJoseph PhiriTaonga MusondaKatie TuscanLinda SandersKurt R. StenmarkPaul W. BuehlerEdford SinkalaDavid C. IrwinSula MazimbaBrian B. Graham

https://doi.org/10.1002/pul2.70230 

 

Abstract

Schistosomiasis and sickle cell disease (SCD) both cause pulmonary hypertension (PH). We identified a subject with sickle cell trait and hepatosplenic schistosomiasis, who on right heart catheterization had PH, but due to high cardiac output. In a pre-clinical model, we found SCD mice were protected from developing schistosomiasis-induced PH.

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