In this Community Call, we discussed:

• Positioning Imatinib for pulmonary arterial hypertension: A dose finding phase 2 study
• Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension

In this Community Call, we discussed:

• Defining echocardiographic degrees of right heart size and function in pulmonary vascular disease from the PVDOMICS study
• Skeletal muscle SIRT3 deficiency contributes to pulmonary vascular remodeling in pulmonary hypertension due to heart failure with preserved ejection fraction

In this Community Call, we discussed:

• An electrocardiogram-based AI algorithm for early detection of pulmonary hypertension
• Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells

In this Community Call, we discussed:

• Deep phenotyping of unaffected carriers of pathogenic BMPR2 variants screened for pulmonary arterial hypertension
• Pulmonary hypertension induced by right pulmonary artery occlusion: hemodynamic consequences of Bmpr2 mutation

In this Community Call, we discussed:

• Digital spatial profiling identifies distinct molecular signatures of vascular lesions in PAH
• Phosphodiesterase-5 inhibitor treatment is associated with improved survival in pulmonary hypertension associated with COPD in the PVRI GoDeep meta-registry

In this Community Call, we discussed:

• Inhaled treprostinil in pulmonary hypertension associated with COPD: PERFECT study results
• Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension

In this Community Call, we discussed: 

• Characteristics and outcomes of patients developing pulmonary hypertension associated with proteasome inhibitors
• Ultrasound neuromodulation of an anti-inflammatory pathway at the spleen improves experimental pulmonary hypertension

In this Community Call, we discussed: 

• Implications of mean pulmonary arterial wedge pressure trajectories in PAH
• Myeloid cell derived IL1β contributes to PH in HFpEF
• Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension

In this Community Call, we discussed: 

• Clinical correlates of a nonplexiform vasculopathy in patients with a diagnosis of idiopathic PAH
• The digital 1-minute walk test: a new patient-centered cardiorespiratory endpoint

In this Community Call, we discussed: 

• RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension 
• Compartment-specific remodeling patterns in end-stage chronic obstructive pulmonary disease with and without severe pulmonary hypertension